Pinoxaden 50 g/ha alone and as tank mixture with and before metsulfuron-methyl 4 g/ha, carfentrazone ethyl 20 g/ha and 2, 4-D 500 g/ha was compared to isoproturon + 2, 4-D, clodinafop fb 2, 4-D, weed free and weedy check for nutrient depletion by weeds and wheat. Phalaris minor and Anagallis arvensis were the major weeds constituting 60.8 and 21.4% of total weed population, respectively. Pinoxaden fb metsulfuron-methyl (50 fb 4 g/ha) remaining at par with pinoxaden + metsulfuron-methyl (50 + 4 g/ha) and pinoxaden + 2,4-D (50 + 500 g/ha) resulted in significantly lower total weed dry weight over rest of the herbicidal treatments. Pinoxaden + metsulfuron-methyl (50 + 4 g/ha) and pinoxaden fb metsulfuron-methyl (50 fb 4 g/ha) were as effective as weed free in reducing N, P and K uptake by weeds. Weeds in weedy check removed 37.4 kg/ha N, 6.9 kg/ha P and 46.8 kg/ha K. Weed free remaining at par with pinoxaden + metsulfuron-methyl (50 + 4 g/ha), pinoxaden fb metsulfuron-methyl (50 fb 4 g/ha) and pinoxaden fb 2, 4-D (50 fb 500 g/ha) resulted in significantly higher wheat dry matter accumulation over rest of the treatments. Weed free gave highest grain yield. However, pinoxaden + metsulfuron-methyl (50 + 4 g/ha), pinoxaden (50 g/ha), pinoxaden + carfentrazone-ethyl (50 + 20 g/ha), pinoxaden fb metsulfuron-methyl (50 fb 4 g/ha), isoproturon + 2, 4-D (1250 + 500 g/ha), clodinafop fb 2, 4-D (60 fb 1000 g/ha), pinoxaden + 2, 4-D (50 + 500 g/ha), pinoxaden fb carfentrazone-ethyl (50 fb 20 g/ha) and pinoxaden fb 2, 4-D (50 fb 500 g/ha) were as good as weed free.