A total of eight treatments were evaluated in a randomized block design (RBD) with three replications. The treatments consisted of pre-emergence application of pendimethalin (30.0% EC) at 1.0 kg/ha + 1 hoeing on 45 DAS, post-emergence application of quizalofop-ethyl 50 g/ha (30 DAS) + 1 hoeing, pendimethalin at 1.0 kg/ha fb quizalofop-ethyl 50 g/ha + 1 hoeing on 45 DAS, post-emergence application of pyrithiobac-sodium 62.5 g/ha (30 DAS) + 1 hoeing on 45 DAS, combination of pyrithiobac-sodium 62.5 g/ha + quizalofop-ethyl 50 g/ha + 1 hoeing on 45 DAS, glyphosate 1.0 kg/ha (45 DAS) as directed spray and control plots of weed free check and unweeded check. The results revealed that application of pre-emergence herbicide pendimethalin at 1.0 kg/ha at 3 DAS followed by post-emergence herbicide (quizalofop-ethyl 50 g/ha at 30 DAS) + one hoeing or combined post-emergence application of pyrithiobac-sodium + quizalofop-ethyl + one hoeing on 45 DAS recorded lesser weed population and weed dry weight and higher weed control efficiency with lower weed index. These treatments were also comparable with pre-emergence application of pendimethalin + 1 hoeing. Higher yield attributes, viz. number of sympodia per plant, number of bolls per plant and boll weight and seed cotton yield were also registered by these treatments. The yield reduction due to weeds accounted 44.8 and 80.3%  during 2012-13 and 2013-14, respectively The economic analysis indicated that higher total income, net income and benefit–cost ratio were associated with pre-emergence application of pendimethalin followed by post-emergence application of quizalofop-ethyl + one hoeing, combined post-emergence application of pyrithiobac-sodium + quizalofop-ethyl + one hoeing and pre-emergence application of pendimethalin + 1 hoeing in both the years of study.