The field experiment was conducted during Rabi season of 2012-13 at Faizabad to study the bio-efficacy of clodinafop-propargyl + metsulfuron-methyl and some other new herbicide molecules against complex weed flora in wheat. Significant reduction density was recorded at different stages of crop growth due to effect of different treatments. As far as the narrow leaved (P. minor) and BLWs were concerned, both type of weeds were effectively controlled by application of clodinafop-propargyl + metsulfuron-methyl 400 g/ha at 32 DAS which was proved superior with respect to number of effective shoots/m2 (0.32) and grain yield (3.95 t/ha) of wheat over rest of the other herbicidal treatments. Lower value of weed index was calculated in clodinafop-propargyl + metsulfuron-methyl 400 g/ha (1.45%) followed by other herbicidal treatments.