A study was conducted during 2014-2015 in College of Horticulture, Vellanikkara, Thrissur to understand response of the Isachne miliacea to common herbicides. Sensitivity of the weed to pre-and post-emergence herbicides were tested using seed and whole plant bioassay techniques, respectively. The pre-emergence herbicides butachlor and oxyfluorfen gave the best results. Among post-emergence herbicides, effective control was observed for azimsulfuron, cyhalofop-butyl and fenoxaprop-p-ethyl. The weed was found to be resistant to pyrazosulfuron. Regrowth was observed after two weeks for bispyribac sodium and penoxsulam. All the non-traditional rice herbicides tested, viz. glyphosate, diuron, paraquat, glufosinate ammonium gave excellent control of the weed.