A field experiment was conducted during Rabi season of 2013-14 at Indira Gandhi Krishi Vishwavidyalaya, Raipur (C.G.) to find out efficient herbicide combinations for weed management in chickpea. Further, significantly higher growth characters viz. plant height, number of branches, dry matter accumulation as well as yield attributes, seed yield, stover yield and harvest index were recorded under hand weeding twice at 25 and 45 DAS, which was at par with tank mix PE application of oxyfluorfen + metribuzin at 125 + 350 g/ha and registered an yield increase of 74.36 and 73.1%, respectively, over control. Metribuzin at 250 g/ha applied at 20 DAS and oxyfluorfen at 125 g/ha applied at 12 DAS showed phytotoxic effects on chickpea plants and recorded reduction in yield of 62.26 and 53.2%, respectively, over hand weeding twice at 25 and 45 DAS. Economics in terms of net return and B:C ratio recorded maximum under oxyfluorfen + metribuzin at 125 + 350 g/ha as PE. Dehydrogenase enzyme activity of experimental field was significantly maximum under control plot, followed by hand weeding twice at 25 and 45 DAS.